Cariogenicity of Streptococcus mutans Glucan-Binding Protein Deletion Mutants



Tooth decay is one of the most common infectious diseases affecting humans and is a significant health care issue in both modern and developing nations. 

Streptococcus mutans Glucan-Binding Protein Deletion Mutants

Streptococcus mutans is widely accepted as one of the most important etiologic agents associated with caries development and has been shown to directly cause caries in germ-free and specific pathogen-free rat models. S. mutans possesses a variety of virulence factors that enable it to establish colonization, utilize a wide array of carbohydrate sources, produce acid and thrive at low pH.

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