Journal and Conferences of Dentistry

Sickness-changes within the oral cavity are to be considering both as the complication of the diabetes as well as the reason of the difficulty in the metabolic compensation of the illness. Every chronic hyperglycaemia, aside from its reasons, leads to the activation of the process of not enzymatic glycation of proteins, poliolic route and the oxidative stress. The chronic hyperglycaemia and related inflammation leads to the disturbances in the balance between the metaloproteinase system and their inhibitors (MMP/TIMP), what becomes a reason of the pathological reconstruction of the vascular wall,the proliferation of the endothelium and arteriogensis . Inflammatory focus in the human body, including the oral cavity, can on one hand be the reason of disturbances of the metabolic control of the diabetes, from the second hand – can accelerate the development hyperglycaemia related vascular complications.  Many authors think that fundamental role in the occurrence of complicat...