Vitamin D and its analogue in treating Periodontal diseases
Vitamin D has the ability to eliminate microbes through diverse mechanisms and biphasic effect on gingival epithelial growth. In concentrations less than equal to 10 nM cell proliferation occurs and in 100 nM suppressed cell growth , whereas Vitamin D analogue shows anti proliferation. Vitamin D and its analogue are involved in wound healing, by activation of vitamin D receptors and increased production of human cathelicidin LL-37. Increase in LL-37 results antimicrobial effect and reduce pro-inflammatory cytokines. These characteristics of Vitamin D proved to be beneficial in treating periodontal diseases. A variety of pathways for the “perioprotective” function of vitamin D have been elucidated. An important property of vitamin D is its ability to induce the antimicrobial peptide, human cathelicidin LL-37, and increase expression of the genes coding for microbial pattern recognition receptors. LL-37 has the ability to eliminate microbes through diverse mechanisms, which might...