Biotechnology & Biomaterials


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Periodontal Intrabony Defects and the Treatment with Enamel Matrix Derivative

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The intrabony defects are considered the main consequence of periodontal disease, presenting itself as a challenge to the clinician. These represent locations that, if untreated, are at an increased risk for disease progression. Although resection surgery has been used a treatment option to their elimination, the treatment of choice is periodontal regeneration . Reports of guided tissue regeneration (GTR) as a periodontal procedure appeared more than 20 years ago. The rationale behind this therapy is to achieve regeneration of tooth supporting structures, or cementum, periodontal ligament and alveolar bone. This is different from conventional periodontal surgery that achieves healing by repair. Another way to approach periodontal regeneration is to mimic the process that occurs during development of periodontal tissues. After the discovery of the presence of a layer of enamel matrix between the peripheral dentin and cementum underdevelopment, along with the ability of this ...
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Herbal Formulation (Tooth Paste): Anti-Precancerous Properties

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Toothpaste can be employed as a vehicle to improve and prevent oral health of individuals and population. Different modalities of treatment are offered for different dental and oral diseases, but the major drawback of these conventional drug therapies are side effects associated with their use. This has led to the interest in the discovery of novel anti-infective natural compounds. The formulation is based on polyherbal extracts which display no side effects on the oral cavity as well as other body organs. To confirm the performance of thetoothpaste formulation, the technology (Oral Sure, Orange Herbs Pvt Ltd, India) was evaluated in vivo on 20 patients (oral leukoplakia, oral lichen planus, submucous fibrosis and erythroplakia). Valid diagnostic tests were evaluated for diagnosing oral pre-cancerous lesions. Pain control and lesion healing were the two main clinical variables for evaluating improvement of oral leukoplakia, oral lichen planus and oral submucous fibrosis. B...
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Vascularised versus Non Vascularised Autogenous Bone Grafts for Immediate Reconstruction of Segmental Mandibular Defects: A Systematic Review

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The mandible is very important for facial aesthetics and is also responsible for mastication and speech. Resection of the mandible is often indicated in the treatment of some infections, odontogenic tumors, severe trauma and oral cancer that represent a great challenge for surgeons because of the complexity and unique anatomy of the mandible. The main target of reconstruction of discontinuity defects of the mandible is to restore  cosmetics, maximize function, mastication and preserve appearance  and quality of life. Treatment of segmental mandibular defects is considered a complex process. Various techniques of reconstruction, ranging from simple bridging plates to composite free flaps have been adopted; each has its advantages and disadvantages. Till now, autogenous bone grafts is still considered to be the gold Standard and the most preferred method in reconstruction of such defects. There are various forms of the autogenous bone grafts either vascularised, non vascularis...
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