Vitamin D Nuclear Receptor and Periodontal Disease
Vitamin D has received increasing attention in recent years beyond its customary role in bone metabolism. There has been an explosion of scientific evidence which suggests the profound role that vitamin D plays in immune homeostasis. Nuclear Receptor Vitamin D nuclear Receptor (VDR) has been identified as a ligand-dependent transcription factor which, in concert with its endogenous ligand, 1,25 hydroxivitamin D (1,25(OH)2D3), is involved in the expression of countless genes. In view of recent research which revealed that most immune cells express the vitamin D nuclear receptor (VDR), the authors reviewed the current knowledge regarding the immunomodulatory effects of vitamin D through its VDR on peridondontal disease. Read More>>>>>>>>>>