A Interdisciplinary Concept of Oral Rehabilitation in a Nonsyndromic Autosomal Dominant Oligodontia with a Novel Mutation of PAX9. A Clinical Report
Agenesis of one or more teeth is one of the most common of human developmental anomalies . Oligodontia is a very rare condition, has a population prevalence of 0.03% to 0.07% and occurs most frequently in females at a ratio of 3:2. The most frequently missing teeth are the maxillary lateral incisors, followed by the mandibular second premolars and the mandibular central incisors . The etiology of tooth agenesis may vary from physical obstruction or disruption of the dental lamina, space limitation and functional abnormalities of the dental epithelium or failure of initiation of the underlying mesenchyme . It may also occur as part of a systemic genetic syndrome or can also be due to an isolated condition (nonsyndromic oligodontia) like mutation in LTBP3 , or mutation in the homeobox gene MSX1 or paired domain transcription factor PAX9. The absence of permanent teeth may cause several clinical problems and the inconvenience to patients will vary, depending on the age,...