Kgp, RgpA, and IL-4 DNA Vaccines Induce Antibody Responses in Experimental Peri-implantitis



Peri-implantitis, which is a major factor leading to implant failure, is an infectious diseases caused by the microbiota such as Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans (Aa), Fusobacterium species (Fs). 

Experimental Peri-implantitis

Among these, Pg, gram-negative anaerobic bacterium, is considered to be the major pathogen causing peri-implantitis. Pg has kinds of virulence factors, such as lipopolysaccharide, fimbriae, haemagglutinins. Pg goes beyond simple adhesion and actively invades and replicates within epithelial cells in vitro. Arginine-specific cysteine proteinase [Arg-gingipain (Rgp), encoded by rgpA and rgpB] and lysine-specific proteinase [Lys-gingipain (Kgp), encoded by kgp] are the predominant extracellular proteolytic enzymes of Pg. 

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