Kgp, RgpA, and IL-4 DNA Vaccines Induce Antibody Responses in Experimental Peri-implantitis
Peri-implantitis,
which is a major factor leading to implant failure, is an infectious diseases
caused by the microbiota such as Porphyromonas gingivalis (Pg), Aggregatibacter
actinomycetemcomitans (Aa), Fusobacterium species (Fs).
Among these, Pg, gram-negative
anaerobic bacterium, is considered to be the major pathogen causing
peri-implantitis. Pg has kinds of virulence factors, such as
lipopolysaccharide, fimbriae, haemagglutinins. Pg goes beyond simple adhesion and
actively invades and replicates within epithelial cells in vitro.
Arginine-specific cysteine proteinase [Arg-gingipain (Rgp), encoded by rgpA and
rgpB] and lysine-specific proteinase [Lys-gingipain (Kgp), encoded by kgp] are
the predominant extracellular proteolytic enzymes of Pg.
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