Autoinducer-2 Signaling: Modulates Cell-Cell Quorum Sensing in Oral Biofilm

The principle of considering dental plaque as biofilm had emerged in the last 10-15 years that totally changes the concept of pathogenesis and control of periodontal diseases. A biofilm environment confers certain properties to bacteria that are not seen in the nomadic state, a fact that explains the importance of recognizing dental plaque as a biofilm and not as bacteria in the planktonic state.
 
Oral Biofilm
Oral Biofilm
Some of the unique properties of biofilm are dependent on the ability of the bacteria and micro-colonies within the biofilm to communicate with one another. Bacteria also harbor vast arrays of mechanisms to sense and respond to features of their environment, including the presence of other bacteria. Small diffusible molecules known as autoinducers are synthesized and released in accordance with cell number; their subsequent detection enables bacteria to synchronously regulate behaviors at the population level in a process known as quorum sensing. Read More>>>>>>>>>>>

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