A Histo-Pathological Study of Liver in 118 Cases of Cirrhosis

Liver diseases and cirrhosis contribute to 23.59% of mortality in world and ranks 27th as major cause of death in world and it is 2.74% of all the causes of death in India but still the exact prevalence of cirrhosis is not known because the disease is often silent so 30% to 40% of cases are discovered at autopsy, indicating that in substantial proportion of people, the disease goes undetected during life. There are various etiologies if cirrhosis and all these causes leave specific imprints upon the liver so as to be identified histologically.
Due to varied etiologies like alcohol which being the commonest, obesity diabetes, hepatitis B, C, all these don’t offer any frontline diagnostic tool nor any treatment modalities to  cirrhosis. Histology only remains a full proof diagnostic tool by which one can hope to identify various causes so quite right fully liver is called as “the custodian of milleu interior”, therefore autopsy study is a need of an hour. I our study we found 118 cases of cirrhosis out of 3960 autopsies which contributes to 14.3% as annual incidence most commonly affecting between 30-50 years of male population. Various gross and microscopic findings were also studied. Such study would be helpful to identify the cause and decide the line of treatment.
Materials and Methods
This was a descriptive cross sectional retrospective (2008-2011) and prospective (2012-2013) study carried out at Lokmanya Tilak Memorial Municipal General Hospital which is a tertiary care hospital in the Department of Pathology which is having Post mortem Histopathology Subunit where daily autopsies are done and prompt histopathology reporting is done. All Cases diagnosed as cirrhosis by gross and microscopic examination duly recorded in autopsy records, included in this study. Out of the total 824 Liver Pathology Cases the 118 number of cases with diagnosis of cirrhosis were selected for the study. All data were obtained from the autopsy history sheet and autopsy records.

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