The Challenge of Treating Oral Infections Caused by Biofilms

In natural systems, the harsh environments, nutrient/respiration needs, and sheer flow, make a community lifestyle preferable or inevitable for microorganisms. Furthermore, the bacteria take advantage of the communities′ organization to protect them from eradication by conventional antimicrobial therapy. A biofilm community is a microorganism aggregate characterized by cells that are attached to a substratum or interface or to each other; are embedded in a matrix of extracellular polymeric substances (EPS) that they have produced; and exhibitan altered phenotype with respect to growth rate and gene transcription. 

Oral Infections Caused by Biofilms


The oral cavity is an example of a challenging environment for the long-term persistence of bacteria and fungi. Fluctuations in nutrient supply, temperature, pH, and the shear force of saliva flow have selected for a biofilm community adapted to high cell density, species diversity, and dynamic growth conditions. The microorganism production of EPS matrix is also very important for their interaction with the environment.  Read more................

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