The Proper Diagnostic Pathway of Gardner’s Syndrome: Role of the Dentist in the Early Detection of the Associated Systemic Pathologies

Gardner’s syndrome, a variant of Familial Adenomatous Polyposis (FAP), is a genetic disorder with highly penetrant autosomal-dominant transmission (80-100%). The incidence of FAP is approximately 1:7500 births, while Gardner’s syndrome occurs in 1:14000 births. 

Gardner’s Syndrome


The first researcher reporting a clinical case characterized by the presence of manifestations which could be ascribed to Gardner’s syndrome was Fitzgerald in 1943, however, the combination of these signs was recognized as a genetically determined syndrome only in 1953 by Gardner e Richards. This disease is characterized by the following triad: Gastrointestinal polyposis, with a 100 percent chance of malignant degeneration, other signs are bone tumors, frequently located on maxillary and cranial bones, and lastly the soft tissues tumors.

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