Use of Fibrin Sealant in Guided Tissue Regeneration of Intrabony Defect

The basic concept of conventional periodontal regenerative treatment is reduction or elimination of tissue inflammation induced by bacterial plaque and its by-products, correction of defects or anatomical problems caused by the disease process, and regeneration of lost periodontal tissues as a consequence of disease destruction. Guided tissue regeneration (GTR) has been widely used for this purpose as it has a “space making effect”, leading to regeneration of periodontium. 


Intrabony Defect
Intrabony Defect-dressing
The rationale of GTR is to place a barrier membrane over the denuded root surface and the debrided periodontal defect to exclude epithelial growth and allow periodontal ligament and alveolar bone cells to repopulate the isolated space. Biodegradable collagen membranes, both synthetic and natural are popular and have been used by several authors. The results have not been consistent with the use of these membrane, some have shown regeneration while others have found no difference when compared against open flap debridement. The varied results seen among them could be explained by lack in expression of biologic potential for regeneration by the barrier membranes. Read more>>>>>>>



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