Further Evidence of GWAS Signals in Non-Syndromic Orofacial Clefts from Western Han Chinese



Non-syndromic orofacial clefts (NSOCs) are the major human congenital defects with a worldwide occurrence rate between 1/700- 1/2500, which varies greatly by geographic origin, ethnicity and socioeconomic status. In general, Asians and Native Americans presented the highest frequencies, sometimes at 1/500 or higher, followed by Caucasians, whereas Africans showed the lowest frequency at approximately 1/2500. 

Non-Syndromic Orofacial Clefts

Especially, Chinese newborns displayed a high frequency of NSOCs at 1.67/1000. The etiologies of NSOCs were multifactorial, with a combination of both genetic and environmental risk factors. The search for genetic factors to NSOCs had used numerous approaches including candidate genes, linkage analysis studies, genomic rearrangements and genomewide association studies (GWAS). However, the results were still unsatisfactory. So far, there were five GWAS of non-syndromic orofacial clefts have been reported and identified tens of susceptible loci.  Read more>>>>>>>>>>>

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